Biomarker Development at Ascendis Pharma in Redwood City, CA
Ascendis PharmaRedwood City, CA
Senior Scientist, Biomarker Development
Do you want to be part of building a fully integrated biopharmaceutical company together with a team of highly skilled colleagues who are passionate about developing best-in-class therapeutics that address significant unmet medical needs?
Then Ascendis Pharma is committed to support your personal development on our journey towards becoming a leading biopharmaceutical company. Ascendis Pharma is looking to hire a Senior Scientist, Biomarker Development to join our team. This is an exciting opportunity to join a rapidly growing, innovative company Position
SummaryThe new biomarker group defines biomarker, translational, and personalized medicine strategies for the Ascendis oncology pipeline. The team is responsible for the generation and analysis of biomarker data from preclinical and clinical studies to determine the therapeutic mechanism of action, demonstrate target modulation, disease modification, and define patient heterogeneity. We seek an experienced, detail-oriented, and results focused scientist who is passionate about therapeutic development and making a difference in patients lives. They will help to define the biomarker strategy, generate and interpret data from preclinical and clinical studies to enable effective therapeutic development. The successful candidate will add their passion, unique talents, and expertise to a dynamic team on the frontlines of cancer biology and innovative therapeutic development. This individual will design and conduct experiments; and, analyze data to advance biomarker discovery and development efforts to impact and inform effective clinical development of our lead assets. Experience in the analysis of complex and multi-dimensional data sets and a strong understanding of oncogenic and immune pathways and tumor biology is highly desirable. This new position is based in Redwood City, CA and will report to the VP Biomarker Development. Key
ResponsibilitiesEstablish and maintain genomics and gene analysis infrastructure and analytic capabilities Design and perform biomarker experiments in house or with collaborators/vendors to generate gene expression data sets (e.g. - bulk RNA-Seq, single cell sequencing, spatial transcriptomics, WES/WGS, Chip
- Seq, Nano.
String, multiplex qPCR, or similar) Apply direct hands-on experience with platforms to generate gene expression data (Nano.
String, 10X Genomics, or others) Collaborate with bioinformatics/statistics colleagues to apply computational tools for analysis and biological interpretation of large datasets Keep abreast the field and provide expertise to help evaluate and ensure access to state-of-the-art biomarker and diagnostic assays Develop biomarker assays in house for pharmacodynamic, predictive, prognostic, safety and other biomarkers Generate, analyse, and interpret complex preclinical and clinical oncology data and communicate findings to project teams and senior leaders Collaborate to develop and execute biomarker and diagnostic strategies, as needed Author biomarker strategy documents and reports, biomarker sections of clinical protocols, regulatory documents, patents, manuscripts and presentations
RequirementsPhD and/or post-doc training in oncology, immune-oncology, tumor biology or other related field with 2 years, MSc with 6 years, or BSc with 8 years of experience - title and salary commensurate with relevant experience Experience in oncology/tumor biology, or immunology with a strong publication record and/or biopharmaceutical industry experience is preferred Provides hands on experience at the bench with a proven ability to synthesize complex data, design and execute experiments Demonstrated experience with genomic, gene expression, or other platforms (e.g. Nano.
String, single-cell/bulk RNA-seq, Chip-seq, microarray or other) Direct experience analyzing, interpreting, and integrating large-scale datasets Expertise in multi-omics and other data analysis in a relevant field Knowledge of biomarker discovery and development: assay development/validation, clinical discovery/application of biomarkers, and translational research Familiarity with drug development process and regulatory filings Knowledge of IP, contracting terms and provisions is desirable Basic understanding of companion diagnostics development is helpful Must be proactive and self-motivated with a strong work ethic, and ability to work independently in a dynamic environment Strong interpersonal skills to enable effective communication, engagement and collaboration with colleagues in a multidisciplinary team environment Candidate must be detail-oriented, organized, and keep excellent records
BenefitsMedical insurance Vision insurance Dental insurance 401(k) Paid maternity leave Paid paternity leave Commuter benefits Disability insurance
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